human bone marrow derived mesenchymal stem cells (hbmscs) have the potential to differentiate into cells such as adipocyte, osteocyte, hepatocyte and endothelial cells. in this study, the differentiation of hbmscs into endothelial like-cells was induced in presence of vascular endothelial growth factor (vegf) and insulin-like growth factor (igf-1). the differentiated endothelial cells were exam...

background: radiation-induced molecular changes on the endothelial surface of brain arteriovenous malformations (avm) may be used as markers for specific vascular targeting agents. in this study, we examined the level of expression of platelet endothelial cell adhesion molecule-1 (pecam-1) on brain endothelial cell surface after radiation treatment, with the aim of targeting the radiation-induc...

objective: endothelium is a selective and permeable membrane for transferring nutrients and vital components to arterial wall. endothelial damage might lead to altered biological function of endothelium and clinical consequences such as atherosclerosis. blood pressure pulse always exerts circumferential tension to the arterial wall. hence, such tension together with other loads, play important ...

background: alzheimer’s disease (ad) is a progressive neurodegenerative disease and nowadays the role of endothelial cell (ec) injury has been proposed in pathological process in ad. peroxisome proliferator‑activated receptor‑γ (ppar‑γ) agonist has anti‑inflammatory properties through activation in glial cells and improves vascular function and prevent atherosclerotic disease progression. the a...

purpose: to compare corneal endothelial cell features after cataract surgery performed using fixed torsional or conventional (pulse) ultrasound mode. methods: in this randomized comparative study, 60 eyes were randomly and equally divided into two groups of torsional or longitudinal mode phacoemulsification. all surgeries were performed by an experienced surgeon, and the outcomes were evaluated...

to evaluate corneal endothelial cell changes after intravitreal and subconjunctival injection of avastin (bevacizumab) based on specular microscopic findings.  this prospective interventional study was performed on 82 eyes of 82 patients. forty-two cases with ptrygia received a subconjunctival injection of bevacizumab (2.5mg/0.2ml) and 40 diabetic subjects with retinal neovascularization or mac...

background: angiogenesis, the formation of new blood vessels from preexisting ones, is one of the most important physiological and pathological processes occur in the body. in the pathological conditions such as tumor growth, psoriasis, corneal neovascularization and rheumatoid arthritis, angiogenesis is crucially required for the devolopment of the disease. zataria multiflora as a member of la...

purpose: to evaluate endothelial cell density (ecd) and morphology of clear corneal grafts after descemet stripping automated endothelial keratoplasty (dsaek) and to determine the factors that influence graft ecd postoperatively. methods: seventy-seven eyes (38 right eyes) of 64 patients (34 female subjects) who underwent dsaek for fuchs’ endothelial dystrophy (n=38) or pseudophakic bullous ker...

purpose: to assess the short-term effect of mitomycin-c (mmc) 0.02% on endothelial cell density and morphology after photorefractive keratectomy (prk) in patients with moderate myopia. methods: forty-two eyes of 21 participants with moderate myopia (range, -4.0 to -8.0 d) underwent prk with mmc 0.02% for 40 seconds. specular microscopy was performed preoperatively and repeated 6 months after su...